2,6-Dichlorobenzaldehyde → (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2,6-dichlorophenyl)methanol

HRID 2046908Notes

Reaction equation

HRID 2046908 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([CH:11]([C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15](F)[C:14]=3[Cl:21])[OH:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.ClC1C=CC=C(Cl)C=1C=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([CH:11]([C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:21])[OH:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 67372,6-DichlorobenzaldehydeHCID 67004517(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,6-dichloro-3-fluorophenyl)methanol

Product 1

HCID 67004341(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2,6-dichlorophenyl)methanol

Procedure

Prepared according to the method described above for synthesis of (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2,6-dichloro-3-fluorophenyl)methanol, using 2,6-dichloro-benzaldehyde. MS (ES+): m/z 370.85, 372.85, 374.83 [MH+]; HPLC: tR=3.25 min (ZQ3, polar—5 min).

Workup

  1. customPrepared
  2. custom5 min

Sources & evidence

ORD record
ord-ee717b16af8f40728480a6d89d4a3669
Source dataset
uspto-grants-2013_11
Patent number
US08592448B2

Reaction notes

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