HRID2046935

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(c1c(Cl)ccc(F)c1Cl)c1c[nH]c2ncc(Br)cc12

HCID58431440

未命名化合物

结构：COC(=O)C(C)(C)n1cc(B2OC(C)(C)C(C)(C)O2)cn1

HCID59599416

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C(C)(C)n1cc(-c2cnc3[nH]cc(C(C)c4c(Cl)ccc(F)c4Cl)c3c2)cn1

HCID67363366

未命名化合物

PROCEDURE

实验过程

Prepared from 5-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridine and 2-methyl-2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]-propionic acid methyl ester according to the Suzuki coupling procedure described in Example 1. Purification by flash column chromatography using 0→70% EtOAc in hexanes afforded the title compound as a light yellow solid. MS (ES+): m/z 475.06/477.04 (100/68) [MH+]. HPLC: tR=2.51 min (ZQ3, polar—5 min).

WORKUP

后处理

customPurification by flash column chromatography