Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,4,6-Trichloro-5-cyanopyrimidine | HCID 250945 | — |
| Reactant | 2-(Propane-2-sulfonyl)aniline | HCID 12646366 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 58290898 | HCID 58290898 | — |
Reaction Steps
To a solution of 2,4,6-trichloropyrimidine-5-carbonitrile (1.0 mmol) and 2-(isopropylsulfonyl)aniline (1.0 mmol) in 5 mL of DMF, was added sodium hydride (24 mg). The suspension was stirred at 30° C. for 2 hours. Product was obtained after work-up and column chromatography (9:1 Hexane:EtOAc). MS (ES+): 371.01 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08592432B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-e7fc88c8666549158c1cbd18d3a7e8b7 |
|---|
| Source note | uspto-grants-2013_11 |
|---|
