Hexane → HCID 58290898, compound

HRID 2046982Notes

Reaction equation

HRID 2046982 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]#[N:10])=[C:4]([Cl:11])[N:3]=1.[CH:12]([S:15]([C:18]1[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=1[NH2:20])(=[O:17])=[O:16])([CH3:14])[CH3:13].[H-].[Na+].CCCCCC>CN(C=O)C.CCOC(C)=O>[Cl:1][C:2]1[N:3]=[C:4]([Cl:11])[C:5]([C:9]#[N:10])=[C:6]([NH:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[S:15]([CH:12]([CH3:14])[CH3:13])(=[O:17])=[O:16])[N:7]=1

Participants

7

Reactant 4

HCID 8058HexaneHCID 24758Sodium hydrideHCID 2509452,4,6-Trichloro-5-cyanopyrimidineHCID 126463662-(Propane-2-sulfonyl)aniline

Product 1

HCID 58290898HCID 58290898, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
30 °C

Procedure

To a solution of 2,4,6-trichloropyrimidine-5-carbonitrile (1.0 mmol) and 2-(isopropylsulfonyl)aniline (1.0 mmol) in 5 mL of DMF, was added sodium hydride (24 mg). The suspension was stirred at 30° C. for 2 hours. Product was obtained after work-up and column chromatography (9:1 Hexane:EtOAc). MS (ES+): 371.01 (M+1)+.

Sources & evidence

ORD record
ord-e7fc88c8666549158c1cbd18d3a7e8b7
Source dataset
uspto-grants-2013_11
Patent number
US08592432B2

Reaction notes

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