Indole-5-carbonitrile → Indole

HRID 2047000Notes

Reaction equation

HRID 2047000 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6](C#N)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.N1C2C(=CC=CC=2)C=C1C#N>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 27513Indole-5-carbonitrileHCID 37875991H-indole-2-carbonitrile

Product 1

HCID 798Indole

Procedure

The A ring indole of compounds 31 and 32 was synthesized using the same approach as 8f described in Scheme 3 above from 1H-indole-5-carbonitrile or 1H-indole-2-carbonitrile as starting material. Crude product was purified by column chromatography.

Workup

  1. customCrude product was purified by column chromatography

Sources & evidence

ORD record
ord-2bd2e6bf7f4e42ca861d7cc2ce9fe268
Source dataset
uspto-grants-2013_11
Patent number
US08592465B2

Reaction notes

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