Ammonia → HCID 67494465, compound

HRID 2047007Notes

Reaction equation

HRID 2047007 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH:11]2[CH2:16][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:14]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:13][CH2:12]2)[CH:3]=1.[NH3:31]>CO>[NH2:31][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH:11]2[CH2:16][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:14]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:13][CH2:12]2)[CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86664778HCID 86664778, compound

Product 1

HCID 67494465HCID 67494465, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

Di-tert-butyl 5-(7-chloropyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1,2-dicarboxylate was dissolved in 30 mL ˜7N ammonia in methanol in a sealed vessel. The reaction mixture was heated at 80° C. for 16 hours. After 16 hours, the reaction mixture is cooled to room temperature and concentrated in vacuo to yield a brown solid. LC-MS: 418 [M+H]. The title compound was used in the next step without further purification.

Workup

  1. temperaturethe reaction mixture is cooled to room temperature
  2. concentrationconcentrated in vacuo
  3. customto yield a brown solid
  4. customThe title compound was used in the next step without further purification

Sources & evidence

ORD record
ord-759223dfb10c48ddb3ceb0cdb012693f
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

Loading…