Ammonia → HCID 67494465, compound

Participants

Reaction Conditions

Reaction Steps

Di-tert-butyl 5-(7-chloropyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1,2-dicarboxylate was dissolved in 30 mL ˜7N ammonia in methanol in a sealed vessel. The reaction mixture was heated at 80° C. for 16 hours. After 16 hours, the reaction mixture is cooled to room temperature and concentrated in vacuo to yield a brown solid. LC-MS: 418 [M+H]. The title compound was used in the next step without further purification.

Provenance & Evidence