Hydrochloric Acid → HCID 67494200, compound

HRID 2047026Notes

Reaction equation

HRID 2047026 reaction equation
C[Si](C)(C)CCOC[N:7](COCC[Si](C)(C)C)[C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[N:19][C:20]4[C:25]([CH:26]=3)=[CH:24][CH:23]=[CH:22][CH:21]=4)=[C:12]2[N:11]=[C:10]([O:27][CH2:28][CH:29]2[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30]2)[C:9]=1[Br:42].Cl>CO.O1CCOCC1>[Br:42][C:9]1[C:10]([O:27][CH2:28][CH:29]2[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]2)=[N:11][C:12]2[N:13]([N:14]=[CH:15][C:16]=2[C:17]2[CH:18]=[N:19][C:20]3[C:25]([CH:26]=2)=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:8]=1[NH2:7]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70215340HCID 70215340, compound

Product 1

HCID 67494200HCID 67494200, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yloxy)methyl)piperidine-1-carboxylate (0.56 g, 68.9 mmol) was dissolved in methanol (6 ml) and treated with 4N hydrochloride solution in dioxane (4 ml) at 65° C. for 30 min. The reaction solution was concentrated and the crude product (0.48 g) was used in the next step without further purification. LC-MS: 453 [M+H].

Workup

  1. concentrationThe reaction solution was concentrated
  2. customthe crude product (0.48 g) was used in the next step without further purification

Sources & evidence

ORD record
ord-ccda7af72ef84e72b78714daabd6f1b3
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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