HRID2047037

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)c1ccc(-c2nc3c(-c4ccc(-c5ccccc5)nc4)cnn3c(N)c2C(C)=O)cc1

HCID66740249

未命名化合物

PRODUCTS

生成物

结构：CC(=O)c1c(-c2ccc(C(=O)O)cc2)nc2c(-c3ccc(-c4ccccc4)nc3)cnn2c1N

HCID66733230

未命名化合物

PROCEDURE

实验过程

Compound methyl 4-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)benzoate was treated with 2 equivalents of LiOH and stirred at room temperature for 4 hrs. Neutralization with dil.HCl and extraction in to organic layer, gave the product, 4-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)benzoic acid in quantitative yield. The compound dissolved in to water-acetonitrile and lyophilized to give a white powder. HPLC-MS tR=1.49 min (UV254 nm); mass calculated for formula C26H19N5O3 449.1, observed LCMS m/z 450.2 (M+H).

WORKUP

后处理

extractionHCl and extraction in to organic layer