(R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester → HCID 68562078, compound

HRID 20471Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH:13]([CH:14]([O:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[CH:15]([N:25]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:12][O:11][C@@H:10]([OH:48])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:49][CH2:50][C:51]1([CH2:56]OS(C(F)(F)F)(=O)=O)[CH2:55][CH2:54][CH2:53][CH2:52]1>>[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([O:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C@@H:15]([N:25]([CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:12][O:11][C@@H:10]([O:48][CH2:56][C:51]2([CH2:50][F:49])[CH2:55][CH2:54][CH2:53][CH2:52]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 68561655(R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester

HCID 86236682Trifluoromethane-sulfonic acid 1-fluoromethyl-cyclopentylmethyl ester

Product 1

HCID 68562078HCID 68562078, compound

Procedure

Beginning with (R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester and trifluoromethane-sulfonic acid 1-fluoromethyl-cyclopentylmethyl ester, the desired compound may be prepared essentially as described in Preparation 306.

Sources & evidence

ORD record: ord-c56912b0849943d6a64374458acfdae2
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07745438B2

Reaction notes

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