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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 20471Generated: October 30, 2026

(R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester → HCID 68562078, compound

https://huagongshe.com/reaction/20471

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl esterHCID 68561655—
ReactantTrifluoromethane-sulfonic acid 1-fluoromethyl-cyclopentylmethyl esterHCID 86236682—
ProductHCID 68562078HCID 68562078—

Reaction Steps

Beginning with (R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester and trifluoromethane-sulfonic acid 1-fluoromethyl-cyclopentylmethyl ester, the desired compound may be prepared essentially as described in Preparation 306.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07745438B2
Source datasetuspto-grants-2010_06
ORD IDord-c56912b0849943d6a64374458acfdae2
Source noteuspto-grants-2010_06