Hydrochloric Acid → HCID 131731058, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-5-thiomorpholinodioxo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile (5 mg), EtOH (1 mL) and 3N HCl (1 mL) was heated at 60° C. until LCMS indicated complete reaction. The mixture was cooled to room temperature and the solvent was evaporated. Purification by prep-LC afforded 7-amino-5-thiomorpholinodioxo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile. LCMS tR=3.12 Min (10 min run, UV254nm). Mass calculated for, M+ 418.12, observed LC/MS m/z 419.2 (M+H).

Provenance & Evidence