Hydrochloric Acid → HCID 131731058, compound

HRID 2047170Notes

Reaction equation

HRID 2047170 reaction equation
C[Si](C)(C)CCOC[N:7](COCC[Si](C)(C)C)[C:8]1[N:13]2[N:14]=[CH:15][C:16]([CH:17]3[C:26](=[O:27])[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][C:18]3=[O:28])=[C:12]2[N:11]=[C:10]([N:29]2[CH2:34][CH2:33][S:32][CH2:31][CH2:30]2)[C:9]=1[C:35]#[N:36].Cl>CCO>[NH2:7][C:8]1[N:13]2[N:14]=[CH:15][C:16]([CH:17]3[C:26](=[O:27])[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][C:18]3=[O:28])=[C:12]2[N:11]=[C:10]([N:29]2[CH2:30][CH2:31][S:32][CH2:33][CH2:34]2)[C:9]=1[C:35]#[N:36]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131731056HCID 131731056, compound

Product 1

HCID 131731058HCID 131731058, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-5-thiomorpholinodioxo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile (5 mg), EtOH (1 mL) and 3N HCl (1 mL) was heated at 60° C. until LCMS indicated complete reaction. The mixture was cooled to room temperature and the solvent was evaporated. Purification by prep-LC afforded 7-amino-5-thiomorpholinodioxo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile. LCMS tR=3.12 Min (10 min run, UV254nm). Mass calculated for, M+ 418.12, observed LC/MS m/z 419.2 (M+H).

Workup

  1. customreaction
  2. temperatureThe mixture was cooled to room temperature
  3. customthe solvent was evaporated
  4. customPurification

Sources & evidence

ORD record
ord-4e26da5191de4fbbb19b8231aa27599a
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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