Pyrazol-3-ylamine → HCID 66735271, compound

HRID 2047179Notes

Reaction equation

HRID 2047179 reaction equation
[C:1]([CH2:3][C:4](=O)[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)#[N:2].[NH:20]1[C:24]([NH2:25])=[CH:23][CH:22]=[N:21]1>CC(O)=O>[NH2:2][C:1]1[N:20]2[N:21]=[CH:22][CH:23]=[C:24]2[N:25]=[C:4]([CH2:5][CH:6]2[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]2)[CH:3]=1

Participants

4

Reactant 2

HCID 74561Pyrazol-3-ylamineHCID 57891190HCID 57891190, compound

Product 1

HCID 66735271HCID 66735271, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The crude tert-butyl 4-(3-cyano-2-oxopropyl)piperidine-1-carboxylate was then heated at 100° C. overnight with 1H-pyrazol-5-amine (1197 mg, 14.41 mmoL) in HOAc (25 mL). Concentration provided crude tert-butyl 4-((7-aminopyrazolo[1,5-a]pyrimidin-5-yl)methyl)piperidine-1-carboxylate.

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-21b2928d13c5471cb8a26a5bd8b4f95d
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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