HCID 66733403, compound → HCID 58173338, compound

Participants

Reaction Steps

5-(4-(1H-pyrazol-4-yl)cyclohex-1-enyl)-6-bromo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine was synthesized in a manner similar to the synthesis of 6-bromo-3-(quinolin-3-yl)-5-(1,2,3,6-tetrahydropyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine, but with 6-bromo-3-(quinolin-3-yl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)-5-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)cyclohex-1-enyl)pyrazolo[1,5-a]pyrimidin-7-amine substituted for tert-Butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate. The reaction mixture was purified via reverse-phase preparatory HPLC to yield 5-(4-(1′-1-pyrazol-4-yl)cyclohex-1-enyl)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine as yellow solid. (M+H=486.12, retention time=3.43 min.

Provenance & Evidence