Hydrochloric Acid → Hydrochloric Acid

HRID 2047207Notes

Reaction equation

HRID 2047207 reaction equation
[CH3:1][C@@H:2]1[CH2:7][CH:6]([NH:8]C(=O)OC(C)(C)C)[CH2:5][C@H:4]([CH3:16])[O:3]1.[ClH:17]>O1CCOCC1>[CH3:1][C@@H:2]1[CH2:7][CH:6]([NH2:8])[CH2:5][C@H:4]([CH3:16])[O:3]1.[ClH:17]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70214528HCID 70214528, compound

Product 2

HCID 313Hydrochloric AcidHCID 667335321251772-69-6

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl (2R,65)-2,6-dimethyltetrahydro-2H-pyran-4-ylcarbamate (crude, 0.6 g) was added 4M HCl in 1,4-dioxane (15 ml) at r.t. It was stirred further at room temperature for 2 h, at which time LC/MS analysis confirmed full consumption of starting material. Solvent was removed in vacuo to get the desired (2R,6S)-2,6-dimethyltetrahydro-2H-pyran-4-amine as an HCl salt.

Workup

  1. customconsumption of starting material
  2. customSolvent was removed in vacuo

Sources & evidence

ORD record
ord-2bca9414f0614126b43613f29b7403ea
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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