Hydrochloric Acid → Hydrochloric Acid

HRID 2047211Notes

Reaction equation

HRID 2047211 reaction equation
[CH3:1][S:2]([CH2:5][C:6]1([NH:9]C(=O)OC(C)(C)C)[CH2:8][CH2:7]1)(=[O:4])=[O:3].[ClH:17]>C(Cl)Cl.O1CCOCC1>[CH3:1][S:2]([CH2:5][C:6]1([NH2:9])[CH2:8][CH2:7]1)(=[O:4])=[O:3].[ClH:17]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 67494427HCID 67494427, compound

Product 2

HCID 313Hydrochloric AcidHCID 62677937HCID 62677937, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 1-(methylsulfonylmethyl)cyclopropylcarbamate (crude, 1.05 g) in DCM (7 ml) was added 4M HCl in 1,4-dioxane (16 ml) at r.t. It was stirred further at room temperature for 1 h, at which time LC/MS analysis confirmed full consumption of starting material. Solvent was removed in vacuo and the solid was washed with ether to get the desired 1-(methylsulfonylmethyl)cyclopropanamine as an HCl salt.

Workup

  1. customconsumption of starting material
  2. customSolvent was removed in vacuo
  3. washthe solid was washed with ether

Sources & evidence

ORD record
ord-0002a012ca7e43068f7cacaba0daa2c5
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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