Water → HCID 66584734, compound

HRID 2047224Notes

Reaction equation

HRID 2047224 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]1[CH:13]=[N:14][N:15]3[C:20]([N:21](COCC[Si](C)(C)C)COCC[Si](C)(C)C)=[CH:19][C:18]([CH:38]([NH:40][CH:41]4[CH2:46][CH2:45][O:44][CH2:43][CH2:42]4)[CH3:39])=[N:17][C:16]=13)=[CH:5]2.O>C(O)(C(F)(F)F)=O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]1[CH:13]=[N:14][N:15]3[C:20]([NH2:21])=[CH:19][C:18]([CH:38]([NH:40][CH:41]4[CH2:42][CH2:43][O:44][CH2:45][CH2:46]4)[CH3:39])=[N:17][C:16]=13)=[CH:5]2

Participants

4

Reactant 2

HCID 962Water2×HCID 66584551HCID 66584551, compound

Product 1

HCID 66584734HCID 66584734, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent2×

Procedure

To a solution of 3-(6-fluoroquinolin-3-yl)-5-(1-(tetrahydro-2H-pyran-4-ylamino)ethyl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)pyrazolo[1,5-a]pyrimidin-7-amine (84 mg, 0.13 mmol) in TFA (2 ml) was added few drops of water and stifling continued for 2 h at room temperature. LC/MS showed no starting material (M.W=666) remaining. TFA along with water was rotoevaporated, and the crude was dried under the high vacuum for 4 h, which was used without further purification for the next step.

Workup

  1. customthe crude was dried under the high vacuum for 4 h
  2. customwhich was used without further purification for the next step

Sources & evidence

ORD record
ord-9e5cd0a14fa4431e928b52af67c8befa
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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