2-(Diethylamino)-6-methylisonicotinic acid → Diethyl-{6-methyl-4-[3-(4-propoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyridin-2-yl}-amine

HRID 2047340Notes

Reaction equation

HRID 2047340 reaction equation
[OH:1][NH:2][C:3](=[NH:14])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH3:13])=[CH:6][CH:5]=1.[CH2:15]([N:17]([CH2:28][CH3:29])[C:18]1[CH:19]=[C:20]([CH:24]=[C:25]([CH3:27])[N:26]=1)[C:21](O)=O)[CH3:16]>>[CH2:28]([N:17]([CH2:15][CH3:16])[C:18]1[CH:19]=[C:20]([C:21]2[O:1][N:2]=[C:3]([C:4]3[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH3:13])=[CH:6][CH:5]=3)[N:14]=2)[CH:24]=[C:25]([CH3:27])[N:26]=1)[CH3:29]

Participants

3

Reactant 2

HCID 584180552-(Diethylamino)-6-methylisonicotinic acidHCID 178458440N-Hydroxy-4-propoxy-benzamidine

Product 1

HCID 68578166Diethyl-{6-methyl-4-[3-(4-propoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyridin-2-yl}-amine

Procedure

The title compound is prepared in analogy to Example 5 starting from N-hydroxy-4-propoxy-benzamidine and 2-diethylamino-6-methyl-isonicotinic acid; LC-MS: tR=1.41*min; [M+1]+=367.09.

Sources & evidence

ORD record
ord-b700d9bb8bdf4c3594647ade2f6f0772
Source dataset
uspto-grants-2013_11
Patent number
US08592460B2

Reaction notes

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