2-(Diethylamino)-6-methylisonicotinic acid → HCID 68578316, compound

HRID 2047342Notes

Reaction equation

HRID 2047342 reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([C:9](=[NH:12])[NH:10][OH:11])[CH:6]=[CH:5][C:4]=1[NH:13][C:14](=[O:16])[CH3:15])[CH3:2].[CH2:17]([N:19]([CH2:30][CH3:31])[C:20]1[CH:21]=[C:22]([CH:26]=[C:27]([CH3:29])[N:28]=1)[C:23](O)=O)[CH3:18]>>[CH2:30]([N:19]([CH2:17][CH3:18])[C:20]1[CH:21]=[C:22]([C:23]2[O:11][N:10]=[C:9]([C:7]3[CH:6]=[CH:5][C:4]([NH:13][C:14](=[O:16])[CH3:15])=[C:3]([CH2:1][CH3:2])[CH:8]=3)[N:12]=2)[CH:26]=[C:27]([CH3:29])[N:28]=1)[CH3:31]

Participants

3

Reactant 2

HCID 584180552-(Diethylamino)-6-methylisonicotinic acidHCID 178436622HCID 178436622, compound

Product 1

HCID 68578316HCID 68578316, compound

Procedure

The title compound is prepared in analogy to Example 5 starting from N-[2-ethyl-4-(N-hydroxycarbamimidoyl)-phenyl]-acetamide and 2-diethylamino-6-methyl-isonicotinic acid; LC-MS: tR=0.81 min, [M+1]+=394.15; 1H NMR (CDCl3): δ 1.25 (t, J=7.0 Hz, 6H), 1.36 (t, J=7.3 Hz, 3H), 2.28 (s, 3H), 2.50 (s, 3H), 2.73 (q, J=7.3 Hz, 2H), 3.63 (q, J=6.8 Hz, 4H), 7.01 (s, 1H), 7.08-7.16 (m, 2H), 8.03-8.09 (m, 2H), 8.13-8.21 (m, 1H).

Sources & evidence

ORD record
ord-a4d0420c31cf41a7b98e2b7a20c0861d
Source dataset
uspto-grants-2013_11
Patent number
US08592460B2

Reaction notes

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