Hydrochloric Acid → HCID 58388241, compound

HRID 2047353Notes

Reaction equation

HRID 2047353 reaction equation
CC([N:5]([C:9]1[S:10][C:11]([Cl:21])=[C:12]([C:15]2[N:19]([CH3:20])[N:18]=[CH:17][CH:16]=2)[C:13]=1[Cl:14])C(=O)[O-])(C)C.Cl>CO>[Cl:14][C:13]1[C:12]([C:15]2[N:19]([CH3:20])[N:18]=[CH:17][CH:16]=2)=[C:11]([Cl:21])[S:10][C:9]=1[NH2:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86656474HCID 86656474, compound

Product 1

HCID 58388241HCID 58388241, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1,1-dimethylethyl[3,5-dichloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbamate (700 mg, 2.010 mmol) in methanol (10.05 ml) at 25° C. was added HCl (10.100 ml, 40.4 mmol)[4M in dioxane]. After 12 h, the reaction mixture was concentrated affording the HCl salt of [3,5-dichloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]amine (640 mg, 1.909 mmol, 95% yield) as a purple foam: LCMS (ES) m/e 284, 286 (M, M+2)+.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-f638ba8499554e7a83d4dc77d147b215
Source dataset
uspto-grants-2013_11
Patent number
US08592475B2

Reaction notes

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