4-[3-(2-Amino-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester → 4-[3-(1H-Benzoimidazol-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

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Reaction Steps

A solution of 4-[3-(2-amino-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (1.20 g, 3.03 mmol) in acetic acid (12 mL) was heated overnight at 55° C., then the solvent was removed under reduced pressure. The solid obtained was triturated with Et2O to afford the title compound as a white solid (0.90 g, 79%) without further purification.

Provenance & Evidence