HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Methyl-2-(3-piperazin-1-yl-phenyl)-1H-benzoimidazole dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 59568200 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-Methyl-2-(3-piperazin-1-yl-phenyl)-1H-benzoimidazole dihydrochloride | HCID 68670433 | — |
Reaction Steps
To a solution of 4-[3-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (1.30 g, 3.32 mmol) in MeOH (4 mL) was added 2M HCl in Et2O (9 mL) and the resulting solution was stirred for 6 h at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592463B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6a3d0e6d3d2d4b91ac01b45740ae0b35 |
| Source note | uspto-grants-2013_11 |