Hydrochloric Acid → 1-Methyl-2-(3-piperazin-1-yl-phenyl)-1H-benzoimidazole dihydrochloride

HRID 2047373Notes

Reaction equation

HRID 2047373 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[N:24]([CH3:25])[C:23]4[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=4[N:21]=3)[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:30]>CO.CCOCC>[ClH:30].[ClH:30].[CH3:25][N:24]1[C:23]2[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=2[N:21]=[C:20]1[C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:15]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 595682004-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 686704331-Methyl-2-(3-piperazin-1-yl-phenyl)-1H-benzoimidazole dihydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 4-[3-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (1.30 g, 3.32 mmol) in MeOH (4 mL) was added 2M HCl in Et2O (9 mL) and the resulting solution was stirred for 6 h at room temperature.

Sources & evidence

ORD record
ord-6a3d0e6d3d2d4b91ac01b45740ae0b35
Source dataset
uspto-grants-2013_11
Patent number
US08592463B2

Reaction notes

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