HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Methyl-2-[3-(4-morpholin-3-ylmethyl-piperazin-1-yl)-phenyl]-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-{4-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazin-1-ylmethyl}-morpholine-4-carboxylic acid tert-butyl ester | HCID 68670186 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Methyl-2-[3-(4-morpholin-3-ylmethyl-piperazin-1-yl)-phenyl]-1H-benzoimidazole | HCID 68671358 | — |
Reaction Steps
To a solution of 3-{4-[3-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazin-1-ylmethyl}-morpholine-4-carboxylic acid tert-butyl ester (0.07 g, 0.15 mmol) in dichloromethane (1 mL) was added 2M HCl in Et2O (3 mL) and the resulting solution was stirred for 7 h at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592463B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-70b3cf4a45474df49f2e857b5860d161 |
| Source note | uspto-grants-2013_11 |