Hydrochloric Acid → 1-Methyl-2-[3-(4-morpholin-3-ylmethyl-piperazin-1-yl)-phenyl]-1H-benzoimidazole

HRID 2047379Notes

Reaction equation

HRID 2047379 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[CH2:14][N:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([C:27]3[N:31]([CH3:32])[C:30]4[CH:33]=[CH:34][CH:35]=[CH:36][C:29]=4[N:28]=3)[CH:22]=2)[CH2:17][CH2:16]1)=O)(C)(C)C.Cl>ClCCl.CCOCC>[CH3:32][N:31]1[C:30]2[CH:33]=[CH:34][CH:35]=[CH:36][C:29]=2[N:28]=[C:27]1[C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([N:18]2[CH2:17][CH2:16][N:15]([CH2:14][CH:9]3[CH2:10][O:11][CH2:12][CH2:13][NH:8]3)[CH2:20][CH2:19]2)[CH:22]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 686701863-{4-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazin-1-ylmethyl}-morpholine-4-carboxylic acid tert-butyl ester

Product 1

HCID 686713581-Methyl-2-[3-(4-morpholin-3-ylmethyl-piperazin-1-yl)-phenyl]-1H-benzoimidazole

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-{4-[3-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazin-1-ylmethyl}-morpholine-4-carboxylic acid tert-butyl ester (0.07 g, 0.15 mmol) in dichloromethane (1 mL) was added 2M HCl in Et2O (3 mL) and the resulting solution was stirred for 7 h at room temperature.

Sources & evidence

ORD record
ord-70b3cf4a45474df49f2e857b5860d161
Source dataset
uspto-grants-2013_11
Patent number
US08592463B2

Reaction notes

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