Piperazin-1-yl-pyrrolidin-1-yl-methanone → HCID 68670755, 화합물

HRID 2047390노트

반응식

HRID 2047390 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C:8]2[N:12]([CH3:13])[C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[N:9]=2)[CH:7]=1.[N:19]1([C:25]([N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)=[O:26])[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[F:18][C:5]1[CH:4]=[CH:3][C:2]([N:22]2[CH2:21][CH2:20][N:19]([C:25]([N:27]3[CH2:28][CH2:29][CH2:30][CH2:31]3)=[O:26])[CH2:24][CH2:23]2)=[CH:7][C:6]=1[C:8]1[N:12]([CH3:13])[C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[N:9]=1

참가 물질

3

반응물 2

HCID 2760443Piperazin-1-yl-pyrrolidin-1-yl-methanoneHCID 595681902-(5-Bromo-2-fluoro-phenyl)-1-methyl-1H-benzoimidazole

생성물 1

HCID 68670755HCID 68670755, 화합물수율 44%

실험 절차

The same procedure described in step c method J was followed but starting from 2-(5-bromo-2-fluoro-phenyl)-1-methyl-1H-benzoimidazole and piperazin-1-yl-pyrrolidin-1-yl-methanone. The crude reaction mixture was purified by preparative HPLC to afford 0.06 g of the title compound (44%).

후처리

  1. customThe crude reaction mixture
  2. customwas purified by preparative HPLC

출처 및 근거

ORD 기록
ord-1deec26b9d6c425fa05ec02448894dcf
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592463B2

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