Hydrochloric Acid → HCID 68670575, compound

Participants

Reaction Steps

To a solution of 2-[5-(4-tert-butoxycarbonyl-piperazin-1-yl)-2-fluoro-phenyl]-benzoimidazole-1-carboxylic acid tert-butyl ester (0.45 g, 0.91 mmol) in DCM (1.0 mL) 2M HCl in Et2O (8.0 mL) was added and the resulting suspension was stirred at room temperature overnight. 2M HCl in Et2O (5.0 mL) more were added and reaction was left stirring for 24 h. The precipitate was filtered off and tritured with Et2O (3×15 mL) to afford 0.21 g of the title compound (55%).

Provenance & Evidence