Hydrochloric Acid → HCID 68670575, compound

HRID 2047395Notes

Reaction equation

HRID 2047395 reaction equation
C(OC([N:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[C:17]1[CH:22]=[C:21]([N:23]2[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]2)[CH:20]=[CH:19][C:18]=1[F:36])=O)(C)(C)C.Cl>C(Cl)Cl.CCOCC>[F:36][C:18]1[CH:19]=[CH:20][C:21]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:22][C:17]=1[C:9]1[NH:8][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68671838HCID 68671838, compound

Product 1

HCID 68670575HCID 68670575, compoundYield 77.9%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-[5-(4-tert-butoxycarbonyl-piperazin-1-yl)-2-fluoro-phenyl]-benzoimidazole-1-carboxylic acid tert-butyl ester (0.45 g, 0.91 mmol) in DCM (1.0 mL) 2M HCl in Et2O (8.0 mL) was added and the resulting suspension was stirred at room temperature overnight. 2M HCl in Et2O (5.0 mL) more were added and reaction was left stirring for 24 h. The precipitate was filtered off and tritured with Et2O (3×15 mL) to afford 0.21 g of the title compound (55%).

Workup

  1. customreaction
  2. waitwas left
  3. stirringstirring for 24 h
  4. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-3ed9723f0d794ba2bf22ca970142c91f
Source dataset
uspto-grants-2013_11
Patent number
US08592463B2

Reaction notes

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