Hydrochloric Acid → 4-(3-Fluoro-piperidin-4-yl)-morpholine

HRID 2047405Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2047405
Cl.C(OC([N:9]1[CH2:14][CH2:13][CH:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH:11]([F:21])[CH2:10]1)=O)(C)(C)C>CCOCC.C(Cl)Cl>[F:21][CH:11]1[CH:12]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)[CH2:13][CH2:14][NH:9][CH2:10]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 686713883-Fluoro-4-morpholin-4-yl-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 686707464-(3-Fluoro-piperidin-4-yl)-morpholine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2.0 N HCl in Et2O (15 mL) was added to a solution of 3-Fluoro-4-morpholin-4-yl-piperidine-1-carboxylic acid tert-butyl ester (1.28 g, 4.44 mmol) in DCM (2 mL) and the resulting suspension was stirred at room temperature 4 days. The precipitate was filtered off and tritured with Et2O (2×5 mL) Na2CO3 saturated solution (10 mL) was added and the resulting solution was concentrated under reduced pressure. EtOH (15 mL) was added and precipitate was filtered off.

Aufarbeitung

  1. filtrationThe precipitate was filtered off
  2. additionwas added
  3. concentrationthe resulting solution was concentrated under reduced pressure
  4. additionEtOH (15 mL) was added
  5. filtrationprecipitate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-cdfbc5302fee41cfa41731399a916830
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592463B2

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