反应详情

2.0 N HCl in Et2O (15 mL) was added to a solution of 3-Fluoro-4-morpholin-4-yl-piperidine-1-carboxylic acid tert-butyl ester (1.28 g, 4.44 mmol) in DCM (2 mL) and the resulting suspension was stirred at room temperature 4 days. The precipitate was filtered off and tritured with Et2O (2×5 mL) Na2CO3 saturated solution (10 mL) was added and the resulting solution was concentrated under reduced pressure. EtOH (15 mL) was added and precipitate was filtered off.

1. filtrationThe precipitate was filtered off
2. additionwas added
3. concentrationthe resulting solution was concentrated under reduced pressure
4. additionEtOH (15 mL) was added
5. filtrationprecipitate was filtered off