1-Methylpiperazine → HCID 44124114, compound

HRID 2047412Notes

Reaction equation

HRID 2047412 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:11]=[C:12]([N:17]2[CH2:22][CH2:21][CH:20]([C:23](O)=[O:24])[CH2:19][CH2:18]2)[CH:13]=[CH:14][C:15]=1[Cl:16].[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[NH:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:1]=[C:2]1[C:10]1[CH:11]=[C:12]([N:17]2[CH2:18][CH2:19][CH:20]([C:23]([N:30]3[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]3)=[O:24])[CH2:21][CH2:22]2)[CH:13]=[CH:14][C:15]=1[Cl:16]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 68671659HCID 68671659, compound

Product 1

HCID 44124114HCID 44124114, compound

Procedure

Synthesized as described in Method X-Step c starting from 1-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperidine-4-carboxylic acid (0.1 g, 0.28 mmol) and 1-methyl-piperazine (37 μL, 0.34 mmol). Obtained 30 mg (24%).

Workup

  1. customSynthesized
  2. customObtained 30 mg (24%)

Sources & evidence

ORD record
ord-49622d3e985f4fc6a60092645c86a287
Source dataset
uspto-grants-2013_11
Patent number
US08592463B2

Reaction notes

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