Acetyl chloride → HCID 68670395, compound

HRID 2047414Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([CH:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([C:29]4[NH:33][C:32]5[CH:34]=[CH:35][CH:36]=[CH:37][C:31]=5[N:30]=4)[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.C(Cl)(=O)C>C(O)(C)C>[NH:30]1[C:31]2[CH:37]=[CH:36][CH:35]=[CH:34][C:32]=2[N:33]=[C:29]1[C:24]1[CH:23]=[C:22]([N:19]2[CH2:20][CH2:21][CH:16]([C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[O:15])[CH2:17][CH2:18]2)[CH:27]=[CH:26][C:25]=1[Cl:28]

Participants

Conditions

Temperature: 40 °C

Procedure

4-{1-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperidine-4-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester (0.05 g, 0.11 mmol) was suspended in isopropanol (4 mL). Acetyl chloride (55 μL, 0.77 mmol) was added dropwise and the reaction mixture was heated to 40° C. until no starting material remained. The reaction was concentrated under reduced pressure to afford 0.05 g of the title compound. (100%).

Workup

concentrationThe reaction was concentrated under reduced pressure

Sources & evidence

ORD record: ord-07ffb1f68d5047dca831b678635914c7
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592463B2

Reaction notes

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