反应详情

温度

60 °C

To a solution of the compound (1.80 g) obtained in step 2 in methanol (10 mL) was added 8N aqueous sodium hydroxide solution (10 mL), and the mixture was stirred at 60° C. for 1.5 hr. The reaction mixture was cooled, and the mixture was acidified with 6N hydrochloric acid, and methanol was evaporated under reduced pressure. The residue was extracted twice with ethyl acetate, dried and concentrated under reduced pressure to give the title compound (1.39 g, 81%) as a white powder.

1. temperatureThe reaction mixture was cooled
2. customwas evaporated under reduced pressure
3. extractionThe residue was extracted twice with ethyl acetate
4. customdried
5. concentrationconcentrated under reduced pressure