Pyrrolidine → HCID 86655863, compound

HRID 2047490Notes

Reaction equation

[F:1][C:2]([F:44])([F:43])[C:3]1[CH:4]=[C:5]([N:13]([CH3:42])[C:14]([N:16]([CH3:41])[C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:20][N:19]([C:29]([O:31]C3C=CC([N+]([O-])=O)=CC=3)=O)[CH2:18]2)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH:45]1[CH2:49][CH2:48][CH2:47][CH2:46]1>>[F:44][C:2]([F:43])([F:1])[C:3]1[CH:4]=[C:5]([N:13]([CH3:42])[C:14]([N:16]([C@H:17]2[C@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:20][N:19]([C:29]([N:45]3[CH2:49][CH2:48][CH2:47][CH2:46]3)=[O:31])[CH2:18]2)[CH3:41])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:10])[F:11])[CH:8]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 86655864HCID 86655864, compound

Product 1

HCID 86655863HCID 86655863, compound

Procedure

By reaction and purification in the same manner as in the method described in Example 420 and using the compound obtained in Example 362 and pyrrolidine, the title compound was obtained.

Workup

customBy reaction and purification in the same manner as in the method

Sources & evidence

ORD record: ord-77039a56b98f4fd8aa29c6f01e328e5e
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592454B2

Reaction notes

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