HCID 178452023, compound → HCID 178494068, compound

HRID 2047530Notes

Reaction equation

[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:36]=[CH:35][C:12]3[N:13]=[C:14]([C@@H:16]4[CH2:19][C@H:18]([N:20]5[CH2:27][C@@H:26]6[C@@H:22]([N:23](C(OC(C)(C)C)=O)[CH2:24][CH2:25]6)[CH2:21]5)[CH2:17]4)[S:15][C:11]=3[CH:10]=2)=[CH:5][N:4]=1.N1C=C(C2C=CC3N=C([C@@H]4C[C@H](N5C[C@@H]6[C@@H](N(C(OC(C)(C)C)=O)CC6)C5)C4)SC=3C=2)C=NC=1>>[NH:23]1[CH2:24][CH2:25][C@@H:26]2[CH2:27][N:20]([C@@H:18]3[CH2:19][C@H:16]([C:14]4[S:15][C:11]5[CH:10]=[C:9]([C:6]6[CH:5]=[N:4][C:3]([O:2][CH3:1])=[N:8][CH:7]=6)[CH:36]=[CH:35][C:12]=5[N:13]=4)[CH2:17]3)[CH2:21][C@H:22]12

Participants

Reactant 2

HCID 178452023HCID 178452023, compound

HCID 178494069HCID 178494069, compound

Product 1

HCID 178494068HCID 178494068, compound

Procedure

The title compound was prepared according to the procedure described in Example 38C, substituting the product of Example 39A for the product of Example 38B. 1H NMR (500 MHz, CDCl3) δ ppm 8.77 (s, 2H) 8.05 (d, J=8.54 Hz, 1H) 7.97 (s, 1H) 7.58 (dd, J=8.54, 1.83 Hz, 1H) 4.08 (s, 3H) 3.85-3.98 (m, 1H) 3.60-3.70 (m, 1H) 3.08-3.16 (m, 1H) 2.90-3.02 (m, 2H) 2.73-2.81 (m, 1H) 2.61-2.71 (m, 2H) 2.49-2.60 (m, 3H) 2.31-2.47 (m, 3H) 1.93-2.05 (m, 1H) 1.58-1.74 (m, 1H). MS: (M+H)+=408.

Sources & evidence

ORD record: ord-57cfd744b088423c918d5dbe15d64653
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592467B2

Reaction notes

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