Diisopropyl Ether → HCID 86658021, compound

HRID 2047574Notes

Reaction equation

HRID 2047574 reaction equation
C(OC(C)C)(C)C.[F:8][C:9]([F:25])([F:24])[C:10]([C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][C:17]=1[OH:23])([OH:15])[C:11]([F:14])([F:13])[F:12].[H][H]>[Ru].O>[F:8][C:9]([F:24])([F:25])[C:10]([CH:16]1[CH2:21][CH2:20][CH:19]([OH:22])[CH2:18][CH:17]1[OH:23])([OH:15])[C:11]([F:12])([F:14])[F:13]

Participants

6

Reactant 3

HCID 7914Diisopropyl EtherHCID 137636924-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-benzenediolHCID 178418361HCID 178418361, compound2×

Product 1

HCID 86658021HCID 86658021, compound

Reagents, catalysts & solvents 2

HCID 23950RutheniumCatalystHCID 962WaterSolvent

Procedure

A pressure-resistant reactor with 2,000 ml of inner capacity, having a stirrer and a thermometer and formed of SUS316, was charged with 800 ml of diisopropyl ether, 350 g (1.27 mol) of Compound 6 and 17.5 g of 5% Ru/C (a product containing 50% of water, produced by N.E. CHEMCAT), and then closed. Thereafter, stirring was started and then the interior of the reactor was substituted with hydrogen, followed by setting hydrogen pressure at 3.0 MPa. The temperature of the reactor was increased and stirring was continued at 130° C. for 20 hours.

Workup

  1. customA pressure-resistant reactor with 2,000 ml of inner capacity, having
  2. customa stirrer and a thermometer and formed of SUS316
  3. customproduced by N.E
  4. customCHEMCAT), and then closed
  5. temperatureThe temperature of the reactor was increased
  6. stirringstirring

Sources & evidence

ORD record
ord-ddd2bda1c0a94fae969c6dbc1d656b03
Source dataset
uspto-grants-2013_11
Patent number
US08592508B2

Reaction notes

Loading…