Hydroxyamine hydrochloride → HCID 2766903, compound

HRID 2047578Notes

Reaction equation

HRID 2047578 reaction equation
Cl.[NH2:2][OH:3].[Br:4][C:5]1[CH:6]=[CH:7][C:8]([O:13][CH2:14][CH:15]=[CH2:16])=[C:9]([CH:12]=1)[CH:10]=O.O1CCOCC1>>[Br:4][C:5]1[CH:6]=[CH:7][C:8]([O:13][CH2:14][CH:15]=[CH2:16])=[C:9]([CH:12]=1)[CH:10]=[N:2][OH:3]

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 86655964HCID 86655964, compound

Product 1

HCID 2766903HCID 2766903, compound

Procedure

A 0.16 mol/L hydroxylamine hydrochloride/1 N sodium hydroxide solution was sent as a first fluid from the center at a ratio of supply pressure/back pressure of 0.15 MPa/0.07 MPa, a rotation speed of 500 rpm, and a sending temperature of 15° C., and a 0.12 mol/L 5-bromo-2-allyloxybenzaldehyde/dioxane solution was introduced as a second fluid into a space between the processing surfaces at 15 mL/min. The first fluid and the second fluid were mixed in a thin film fluid, and then a solution obtained after processing was discharged from the space between the processing surfaces at 30 mL/min. As a result of HPLC analysis, substantially complete conversion to 5-bromo-2-allyloxybenzaldoxime was observed.

Workup

  1. additionThe first fluid and the second fluid were mixed in a thin film fluid
  2. customa solution obtained after processing

Sources & evidence

ORD record
ord-8c82bf2ea2ff4524937d307a6d6b0693
Source dataset
uspto-grants-2013_11
Patent number
US08592498B2

Reaction notes

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