Hydrazine hydrate (1:1) → HCID 62678395, compound

HRID 2047643Notes

Reaction equation

HRID 2047643 reaction equation
O.[NH2:2][NH2:3].C([O:6][C:7](=O)[C:8]([CH3:12])([CH3:11])[CH2:9][CH3:10])C>>[CH3:11][C:8]([CH3:12])([CH2:9][CH3:10])[C:7]([NH:2][NH2:3])=[O:6]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12647075Ethyl 2,2-dimethylbutanoate

Product 1

HCID 62678395HCID 62678395, compoundYield 61.8%

Procedure

Reflux a mixture of hydrazine monohydrate (0.97 g, 19.4 mmol) and 2,2-dimethyl-butyric acid ethyl ester (1.4 g, 9.7 mmol) for 72 hours. Purify the crude material by flash chromatography (silica gel) using 5% (7 M ammoniated methanol) in dichloromethane to afford the title compound (0.78 g). 1H NMR (CDCl3) δ 0.81 (t, 3H), 1.13 (s, 6H), 1.53 (q, 2H), 3.88 (s, 2H), 7.05 (bs, 1H).

Workup

  1. temperatureReflux
  2. customPurify the crude material by flash chromatography (silica gel)

Sources & evidence

ORD record
ord-48c2c415982b4132b4270e2108bcc8a0
Source dataset
uspto-grants-2013_11
Patent number
US08592590B2

Reaction notes

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