Ethyl Acetoacetate → HCID 66746144, compound

HRID 2047741Notes

Reaction equation

HRID 2047741 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[C:3]=1[C:4]#[N:5].O=[C:17]([CH3:24])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[CH2:22]([O:21][C:19]([C:18]1[C:17]([CH3:24])=[N:1][C:2]2[C:3]([C:4]=1[NH2:5])=[C:6]([O:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1)[CH:7]=[CH:8][CH:9]=2)=[O:20])[CH3:23]

Participants

3

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 66747177HCID 66747177, compound

Product 1

HCID 66746144HCID 66746144, compound

Procedure

Prepared as in Example 2a from 2-amino-6-(cyclopentyloxy)benzonitrile (Tachdjian, C. et al. PCT Int. Appl. 2008, WO 2008154221) and ethyl 3-oxobutanoate as a yellow solid (40%). MS 315 (MH+).

Sources & evidence

ORD record
ord-0b5a35a2b29e4e239c8f1e8302a10407
Source dataset
uspto-grants-2013_11
Patent number
US08592592B2

Reaction notes

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