Ethyl Acetoacetate → HCID 66746886, compound

HRID 2047782Notes

Reaction equation

[NH2:1][C:2]1[C:3]([C:21]#[N:22])=[C:4]([CH:18]=[CH:19][CH:20]=1)[O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[NH:12][C:13](=[O:17])[CH:14]([CH3:16])[CH3:15].O=[C:24]([CH3:31])[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[CH2:29]([O:28][C:26]([C:25]1[C:24]([CH3:31])=[N:1][C:2]2[C:3]([C:21]=1[NH2:22])=[C:4]([O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[NH:12][C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[CH:18]=[CH:19][CH:20]=2)=[O:27])[CH3:30]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 66747165HCID 66747165, compound

Product 1

HCID 66746886HCID 66746886, compound

Procedure

Prepared as in Example 2a from N-(2-(3-amino-2-cyanophenoxy)cyclohexyl)isobutyramide (Example 39b) and ethyl 3-oxobutanoate as a yellow solid (63%). MS 414 (MH+).

Sources & evidence

ORD record: ord-d32605a709864ad6a8d3b263d49d3cb4
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592592B2

Reaction notes

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