Ethyl Acetoacetate → HCID 66745909, compound

HRID 2047785Notes

Reaction equation

HRID 2047785 reaction equation
[NH2:1][C:2]1[C:3]([C:21]#[N:22])=[C:4]([CH:18]=[CH:19][CH:20]=1)[O:5][CH:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[CH2:8][CH2:7]1.O=[C:24]([CH3:31])[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[CH2:29]([O:28][C:26]([C:25]1[C:24]([CH3:31])=[N:1][C:2]2[C:3]([C:21]=1[NH2:22])=[C:4]([O:5][CH:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[CH2:10][CH2:11]1)[CH:18]=[CH:19][CH:20]=2)=[O:27])[CH3:30]

Participants

3

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 66745656N-(4-(3-amino-2-cyanophenoxy)cyclohexyl)isobutyramide

Product 1

HCID 66745909HCID 66745909, compound

Procedure

Prepared as in Example 2a from N-(4-(3-amino-2-cyanophenoxy)cyclohexyl)isobutyramide (Example 40b) and ethyl 3-oxobutanoate as a yellow solid (57%). MS 414 (MH+).

Sources & evidence

ORD record
ord-ac8b1a18cb304a89adfe7d14a706e527
Source dataset
uspto-grants-2013_11
Patent number
US08592592B2

Reaction notes

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