5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine → Ethyl 4-amino-5-(3-((5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylate

HRID 2047807Notes

Reaction equation

HRID 2047807 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C:14]([CH3:19])([CH3:18])[C:15]([OH:17])=O)[N:5]=[C:4]([CH3:20])[C:3]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22].[CH3:26][O:27][C:28]1[CH:37]=[CH:36][CH:35]=[C:34]2[C:29]=1[CH2:30][CH2:31][CH2:32][CH:33]2[NH2:38]>>[CH2:24]([O:23][C:21]([C:3]1[C:4]([CH3:20])=[N:5][C:6]2[C:11]([C:2]=1[NH2:1])=[C:10]([O:12][CH2:13][C:14]([CH3:19])([CH3:18])[C:15]([NH:38][CH:33]1[C:34]3[C:29](=[C:28]([O:27][CH3:26])[CH:37]=[CH:36][CH:35]=3)[CH2:30][CH2:31][CH2:32]1)=[O:17])[CH:9]=[CH:8][CH:7]=2)=[O:22])[CH3:25]

Participants

3

Reactant 2

HCID 388995-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amineHCID 667468783-((4-Amino-3-(ethoxycarbonyl)-2-methylquinolin-5-yl)oxy)-2,2-dimethylpropanoic acid

Product 1

HCID 66746982Ethyl 4-amino-5-(3-((5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylate

Procedure

Prepared as in Example 24a from 3-((4-amino-3-(ethoxycarbonyl)-2-methylquinolin-5-yl)oxy)-2,2-dimethylpropanoic acid (Example 47b) and 5-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine as a brown solid (40%). MS 506 (MH+).

Sources & evidence

ORD record
ord-7025330e9bf848a4b38dd84bdcc93499
Source dataset
uspto-grants-2013_11
Patent number
US08592592B2

Reaction notes

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