Ethyl Acetoacetate → HCID 66746461, compound

HRID 2047854Notes

Reaction equation

[NH2:1][C:2]1[C:3]([C:26]#[N:27])=[C:4]([CH:23]=[CH:24][CH:25]=1)[O:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][CH2:9][N:8]1C(OCC1C=CC=CC=1)=O.O=[C:29]([CH3:36])[CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[CH2:34]([O:33][C:31]([C:30]1[C:29]([CH3:36])=[N:1][C:2]2[C:3]([C:26]=1[NH2:27])=[C:4]([O:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][CH2:9][NH:8]1)[CH:23]=[CH:24][CH:25]=2)=[O:32])[CH3:35]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 66746342HCID 66746342, compound

Product 1

HCID 66746461HCID 66746461, compound

Procedure

Prepared as in Example 2a from benzyl 2-((3-amino-2-cyanophenoxy)methyl)piperidine-1-carboxylate (Example 111c) and ethyl 3-oxobutanoate as a colorless oil (13%). MS 344 (MH+).

Sources & evidence

ORD record: ord-451eab6406f24ad7838b45cef605731f
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592592B2

Reaction notes

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