Ethyl Acetoacetate → HCID 66746776, compound

HRID 2047860Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=2)[C:3]=1[C:16]#[N:17].O=[C:19]([CH3:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH2:24]([O:23][C:21]([C:20]1[C:19]([CH3:26])=[N:1][C:2]2[C:3]([C:16]=1[NH2:17])=[C:4]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[CH:5]=[CH:6][CH:7]=2)=[O:22])[CH3:25]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 66747101HCID 66747101, compound

Product 1

HCID 66746776HCID 66746776, compound

Procedure

Prepared as in Example 2a from 3-amino-3′-methoxy-[1,1′-biphenyl]-2-carbonitrile (Example 114b) and ethyl 3-oxobutanoate as a pale yellow solid (55%). MS 337 (MH+).

Sources & evidence

ORD record: ord-2e6379d19b324fdfb266b9a4ec76049b
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592592B2

Reaction notes

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