Ethyl Acetoacetate → HCID 86658230, compound

HRID 2047883Notes

Reaction equation

[NH2:1][C:2]1[C:3]([C:30]#[N:31])=[C:4]([CH:27]=[CH:28][CH:29]=1)[O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[O:12][C:13]1[CH:14]=[C:15]([CH:22]=[CH:23][C:24]=1[O:25][CH3:26])[C:16]([NH:18][CH:19]([CH3:21])[CH3:20])=[O:17].O=[C:33]([CH3:40])[CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36]>>[NH2:31][C:30]1[C:3]2[C:2](=[CH:29][CH:28]=[CH:27][C:4]=2[O:5][CH:6]2[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]2[O:12][C:13]2[CH:14]=[C:15]([C:16](=[O:17])[NH:18][CH:19]([CH3:21])[CH3:20])[CH:22]=[CH:23][C:24]=2[O:25][CH3:26])[N:1]=[C:33]([CH3:40])[C:34]=1[C:35]([O:37][CH2:38][CH3:39])=[O:36]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 66747192HCID 66747192, compound

Product 1

HCID 86658230HCID 86658230, compound

Procedure

Prepared as in Example 2a from (±)-3-((2-(3-amino-2-cyanophenoxy)cyclohexyl)oxy)-N-isopropyl-4-methoxybenzamide (Example 129b) and ethyl 3-oxobutanoate as a yellow solid (78%). MS 536 (MH+).

Sources & evidence

ORD record: ord-2b925a75f05f421a8bc0cd900f36fda8
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592592B2

Reaction notes

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