Hydrochloric Acid → Methyl 5-chloro-2,4-difluorobenzoate

HRID 2048042Notes

Reaction equation

HRID 2048042 reaction equation
[Cl:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].Cl.[CH3:14]O>>[Cl:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:14])=[O:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 148764175-Chloro-2,4-difluorobenzoic acid

Product 1

HCID 58042369Methyl 5-chloro-2,4-difluorobenzoate

Procedure

A solution of 5-chloro-2,4-difluorobenzoic acid (2.8 g, 15 mmol) in a solution of HCl in methanol (4 M, 10 mL) was stirred at 60° C. for 4 hours. The reaction was cooled down and the solvent was evaporated to afford the title compound, which was used for the next step without further purification.

Workup

  1. temperatureThe reaction was cooled down
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-870b9304e82842509ee1c97a78578514
Source dataset
uspto-grants-2013_11
Patent number
US08592629B2

Reaction notes

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