反应详情

温度

40 °C

Di-tert-butyl carbonate (4.95 g, 22.7 mmol) was added to a solution of 2,4,6-trifluorobenzoic acid (2.0 g, 11.3 mmol) and 4-dimethylaminopyridine (139 mg, 1.14 mmol) in tBuOH (30 mL) and the reaction mixture was heated at 40° C. for 18 hours. The reaction mixture was then quenched with aqueous 1M HCl and extracted into EtOAc. The combined organics were washed with aqueous 1M NaOH, followed by brine, dried and concentrated in vacuo to afford the title compound as a pale yellow oil (2.63 g, 52% yield):

1. customThe reaction mixture was then quenched with aqueous 1M HCl
2. extractionextracted into EtOAc
3. washThe combined organics were washed with aqueous 1M NaOH
4. customdried
5. concentrationconcentrated in vacuo