Trifluoroacetic acid → HCID 58042467, compound

HRID 2048089Notes

Reaction equation

HRID 2048089 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:21]=[C:20]([O:22][C:23]2[CH:24]=[N:25][C:26]([CH:30]3[CH2:32][CH2:31]3)=[C:27]([Cl:29])[CH:28]=2)[C:19]([Cl:33])=[CH:18][C:10]=1[C:11]([O:13]C(C)(C)C)=[O:12]>ClCCl>[Cl:8][C:9]1[CH:21]=[C:20]([O:22][C:23]2[CH:24]=[N:25][C:26]([CH:30]3[CH2:32][CH2:31]3)=[C:27]([Cl:29])[CH:28]=2)[C:19]([Cl:33])=[CH:18][C:10]=1[C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58042474HCID 58042474, compound

Product 1

HCID 58042467HCID 58042467, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (42 μL, 0.56 mmol) was added to a solution of tert-butyl 2,5-dichloro-4-(5-chloro-6-cyclopropylpyridin-3-yloxy)benzoate (Preparation 219, 116 mg, 0.28 mmol) in dichloromethane (3 mL). The reaction mixture was stirred at room temperature for 4 hours then concentrated in vacuo. The residue was dissolved in methanol (10 mL) then concentrated in vacuo to afford the title compound as colourless solid (100 mg, 100%).

Workup

  1. concentrationthen concentrated in vacuo
  2. dissolutionThe residue was dissolved in methanol (10 mL)
  3. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-5255efaacc584dc993062bca43fb9d9a
Source dataset
uspto-grants-2013_11
Patent number
US08592629B2

Reaction notes

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