tert-butyl 4-[[(Z)-[amino(pyridin-2-yl)methylidene]amino]carbamoyl]piperidine-1-carboxylate → HCID 178451825, compound

HRID 2048129Notes

Reaction equation

[NH2:1]/[C:2](/[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1)=[N:3]\[NH:4][C:5]([CH:7]1[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH2:8]1)=O>C(O)C>[N:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:2]1[NH:3][N:4]=[C:5]([CH:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH2:8]2)[N:1]=1

Participants

Conditions

Temperature: 150 °C

Procedure

Tert-butyl 4-({(2Z)-2-[amino(pyridin-2-yl)methylidene]hydrazinyl}carbonyl)piperidine-1-carboxylate 45 g (129 mM) obtained in step II is melted at 220° C. under nitrogen atmosphere for 1 hr. Reaction is then cooled to 150° C. and added ethanol till solid get dissolved. Ethanol is then evapourated to get desired compound.

Workup

customfor 1 hr
customReaction
customget
dissolutiondissolved

Sources & evidence

ORD record: ord-6f82ff686d974c87b1b6bb3c92e20161
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592591B2

Reaction notes

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