2-Aminopyrimidine → HCID 86631773, compound

HRID 2048133Notes

Reaction equation

HRID 2048133 reaction equation
Br[CH:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1)=O.[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[NH2:25]>CN(C=O)C>[C:13]1([C:2]2[N:19]3[CH:24]=[CH:23][CH:22]=[N:21][C:20]3=[N:25][C:3]=2[C:5]2[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 79782-AminopyrimidineHCID 53434504HCID 53434504, compound

Product 1

HCID 86631773HCID 86631773, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.6 g 4-[bromo(phenyl)acetyl]benzaldehyde and 1.64 g pyrimidin-2-amine are stirred in 140 ml DMF at 90° C. for 4 h. The DMF is evaporated and the residue suspended in ethylacetat over night, collected by filtration.

Workup

  1. customThe DMF is evaporated
  2. waitthe residue suspended in ethylacetat over night
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-70669de3ac1d4232aa670092a7d59d04
Source dataset
uspto-grants-2013_11
Patent number
US08592591B2

Reaction notes

Loading…